At the Xavier Center, Brycen Martin and Daniel Santaniello combined for 17 of Scranton Prep's 23 points in the fourth quarter as the second-seeded Cavaliers rallied for a semifinal win.
Santaniello finished with 18 points for Scranton Prep and Martin had 15.
Jaidyn Johnson scored 27 points for No. 3 Nanticoke and Ibn Jordan Thomas had 16.